Explosions were heard in Tehran early Wednesday as intense Israeli airstrikes again targeted Iran’s capital in a conflict that a human rights group said had killed at least 585 people across Iran and wounded 1,

For nearly six nights, sirens have blared across Israel warning of retaliatory Iranian strikes. While Israel is able to inflict far greater pain on Iran, it has not been immune to destruction and death.

The intensifying conflict has heightened fears of a protracted all-out war and widespread instability in the region.