Emergency services say ten have been killed in Israel, while Iranian state media have given little information about casualties in Iran.

Iranian media reported that Israel struck the South Pars Gas Field in what would be the first attack on an Iranian energy site.

Sen. Lindsey Graham (R., S.C.) said in a social media post that if Iran doesn't take up President Trump's offer to return to the negotiating table, the U.S. should "go all-in to help Israel finish the job.

The Israeli Air Force (IAF) says it has destroyed "dozens" of radars and surface-to-air missile launchers as part of the attacks on Iran's air defence systems in the west of the country. Calling it a "large-scale strike", the IAF says this forms part of ongoing operations to damage Iran's air defence systems and those of its proxies.

Russia has maintained a delicate balancing act in the Middle East for decades, trying to navigate its warm relations with Israel even as it has developed strong economic and military ties with Iran.

The head of the United Nations atomic agency, Rafael Grossi, said Iran told the agency that Israel attacked the Fordow enrichment plant on Friday, meaning Israel struck the three core sites of Iran's nuclear program.

President Donald Trump told Reuters in a phone interview on Friday that it was unclear if Iran still has a nuclear program following Israeli strikes on the country. Trump told Reuters the U.S. still has nuclear talks planned with Iran on Sunday but that he is not sure if they will still take place.

Israel launched an expanded assault on Iran on Sunday, targeting its energy industry and Defense Ministry headquarters, while Tehran unleashed a fresh barrage of deadly strikes. The simultaneous attacks represented the latest burst of violence since a surprise offensive by Israel two days earlier aimed at decimating Tehran’s rapidly advancing nuclear program.