After a long-running feud, Novak Djokovic and Nick Kyrgios developed a bromance and are now celebrating their first win as a doubles pair.

The new doubles team of Novak Djokovic and Nick Kyrgios are out of the Brisbane International in the second round. The pair, granted a wild-card entry by tournament organizers, lost 6-2, 3-6, 10-8 Wednesday to the top-seeded team of Nikola Mektic of Croatia and New Zealander Michael Venus.

Kyrgios, who revealed after his singles comeback on Tuesday that he is still struggling with pain in the wrist that has kept him out for 18 months, produced two through-the-legs shots in one memorable rally, and he and Djokovic looked poised for victory at 8-6 ahead in the deciding tie-break.

After all the talk and bluster, Nick Kyrgios finally returned to the court for a professional tennis match. Kyrgios missed the better part of two years due to injuries and returned in style alongside Novak Djokovic for a highly publicized doubles match.

Novak Djokovic and Nick Kyrgios enthralled fans on their debut as a doubles team on Monday, riding a massive wave of support to secure a 6-4 6-7(4) (10-8) win over Alexander Erler and Andreas Mies at the Brisbane International.

Australian wildcard Kimberly Birrell stunned second seed Emma Navarro on Wednesday while the doubles act of Novak Djokovic and Nick Kyrgios came to a shuddering halt at the Brisbane International. But it was all smiles from defending men's champion Grigor Dimitrov, who powered into the quarter-finals in straight sets.

Novak Djokovic and Nick Kygrios are narrowly beaten in the second round of the doubles at the Brisbane International.

Grigor Dimitrov stayed on course for his title defence but women's second seed Emma Navarro was stunned by local favourite Kimberly Birrell at the Brisbane International on Wednesday.

Highlights, stats, and videos from Novak Djokovic and Nick Kyrgios' doubles loss at the Brisbane International.