Former Vice President Mike Pence said on “State of the Union” Sunday that if Israel’s attack doesn’t somehow convince Iran to make major concessions in Trump’s diplomatic attempt to end its nuclear program, then the United States should be prepared to join the conflict.

President Trump rejected an Israeli plan in recent days to kill Iran's Supreme Leader Ayatollah Ali Khamenei, a senior U.S. official told USA TODAY.

Israel and Iran exchange airstrikes targeting military sites and nuclear facilities, with Trump comments on the conflict and expressing optimism for diplomatic resolution.

President Donald Trump on Sunday issued a stark warning to Iran against retaliating on U.S. targets in the Middle East while also predicting Israel and Iran would “soon” make a deal to end their escalating conflict.

President Trump opposed a recent Israeli plan to kill Iran's Supreme Leader Ayatollah Ali Khamenei, three U.S. officials told CBS News on Sunday.

"The full strength and might of the U.S. Armed Forces will come down on you at levels never seen before," Trump warned.

The U.S. was represented at the UN Security Council's emergency session on Friday by State Department Senior Bureau Official McCoy Pitt, who said the U.S. was advised by Israel that the actions carried out against Iran overnight were "necessary for its self-defense."

President Donald Trump said the United will come down on Iran “at levels never seen before” if the Middle Eastern country attacks.

President Donald Trump said he believed it’s possible Israel and Iran could reach an agreement to end their conflict, though the two sides may need to continue fighting before they’re ready to broker a peace deal.

Iran launched multiple deadly waves of missiles and drones toward Israel into Saturday morning following Israel’s unprecedented strikes aimed at destroying Iran’s nuclear program and decapitating its military leadership.