Subsequently, the CRISPR–Cas13 system has emerged as a potential tool to identify and rectify errors in RNA sequences. CRISPR–Cas13 is a novel technology specifically engineered for virus ...

Subsequently, the CRISPR–Cas13 system has emerged as a potential tool to identify and rectify errors in RNA sequences. CRISPR–Cas13 is a novel technology is specifically engineered for virus ...

Qi and his colleagues used a version of the gene-editing tool CRISPR, called CRISPR-Cas13, to target individual pieces of RNA (unlike the more widely known CRISPR-Cas9, which targets DNA). Typically, ...

Type VI CRISPR-Cas systems contain the programmable single-effector RNA-guided RNases Cas13. Here, we profile Type VI systems to engineer a Cas13 ortholog capable of robust knockdown and demonstrate ...

Rather than the popular DNA-editing CRISPR-Cas9 technique, the new approach uses CRISPR-Cas13, which can target mRNA—the messenger molecule that carries protein blueprints transcribed from DNA.

The CRISPR used in today’s study is called CRISPR-Cas13. Instead of snipping DNA, this type of CRISPR targets another of the major biological molecules found in all forms of life, RNA.

When they infected E. coli with a phage (virus that attacks bacteria) and deployed the CRISPR-Cas13 system to target and halt infection, they found that Cas13 signals to Csx28 to affect membrane ...

Through transcript-specific mechanisms that are independent of the CRISPR RNA sequence and dynamically dependent on the conformational state of Cas13, Cas13 can also cleave host RNA. This effect ...