These new bonds were only discovered in 2016, and are formed when the end of a lysine side-chain is linked to the end of a cysteine side-chain with an oxygen atom linking them together.

Prior to 2000, many drugs that formed a covalent bond with targets did so non-selectively, which often led to undesired side effects when compared to non-covalent drugs. This led to the belief that ...

Covalent chemical probes – chemical probes that form a covalent bond with their target biomacromolecule(s) represent powerful tools that can be used for biology discovery, target validation (or ...