the fat-busting protein leptin, scientists have been racing to understand and apply this modern marvel. The ob gene -- ob for obesity -- was moved into mice in 1995, and the photo of the fat mouse ...

As things turned out, however, the Laboratory provided a very fertile environment—with excellent colleagues and world-class mouse models of ... one abnormality: the fat pads were smaller in ...

Though a complex interplay of genes, diet, and environment contribute, 90% of cases share one thing in common: leptin resistance. In lean individuals, fat cells produce the hormone leptin, which ...

Researchers say study findings have important implications for our understanding of the pathogenesis of obesity and potential therapeutic applications.

This new potential therapy harnesses the power of GLP-1 while activating the receptor for leptin, a hormone released by fat cells that ... produce weight loss in a mouse where leptin by itself ...

In recent years, for instance, studies have indicated that fat is far from the lone culprit in human weight gain, and that carbohydrates play a hefty role. “Mice are a good model for human obesity . .

Wild-type ADP, globular ADP, Cys36Ser ADP, the tail domain of ADP, or leptin was administered ... Technical expertise for mouse studies was provided by the Penn Diabetes Center Mouse Phenotyping ...