More than 100 million people in the U.S. will be in the path of an intense March storm starting Friday as the sprawling multi-day system threatens fires, blizzards, tornadoes, and flooding as it tracks eastward across the Great Plains.

The forecast comes days after an expansive storm similarly trekked across the U.S. last week, unloading snow in the northern Plains and bringing tornadoes and wildfires to the South. At least five storm-related deaths in Nebraska and Mississippi were tied to that storm.

The threat of violent tornadoes in parts of the U.S. proved deadly as well as destructive as whipping winds moved east into the Mississippi Valley and Deep South on Saturday, with at least 16 people killed and scores of homes decimated.