Gupta's study identified a process that prevents progenitor cells from developing into fat cells in mouse subcutaneous inguinal fat. The protein HIF-1a (short for hypoxia-inducible factor-1 alpha ...

They assessed serum and tissues, as well as isolated cells from a fat deposit (inguinal) equivalent to human gluteal and thigh fat, for molecular and phenotypic changes, as well as metabolism ...

In the mouse model, targeting a specific fat depot with weekly injections of nanoparticles ... Importantly, focal injection of these NPs into the inguinal white adipose tissue depots of diet-induced ...

In Gupta's mouse study, researchers used a genetic approach to inhibit HIF-1a and found that the progenitor cells could then make subcutaneous inguinal fat cells and fewer were inflamed or fibrotic.