In this paper, we review the case of studies with lamotrigine in bipolar disorder, describing evidence of lack of efficacy in multiple mood states outside of the primary area of efficacy ...

We tested valproate, topiramate and lamotrigine in the MPTP mouse model. Dopamine transporter (DAT) density was assessed by quantitative autoradiography, tyrosine hydroxylase (TH) was evaluated by ...

All forms of Lamictal, except extended-release tablets, are also approved to help regulate mood in adults with bipolar 1 disorder. Lamictal extended-release tablets (Lamictal XR) are approved for ...

We then focused on the results provided for the agent with the largest number of negative studies available, lamotrigine. Of major US pharmaceutical companies, so far only GSK has provided data on ...