Nature14y
The colony-stimulating factors and cancer
The four colony-stimulating factors (CSFs) are glycoproteins that regulate the generation and some functions of infection-protective granulocytes and macrophages. Recombinant granulocyte-CSF (G ...
EurekAlert!2d
CSF multi-omics of intracerebral hemorrhage from onset to reperfusion underscores lipid metabolism in functional outcome
In a paper published in Science Bulletin, multi-omics analyses comprising of lipidomics (439 lipids), sterolomics (22 ...
SynOx Therapeutics Further Strengthens Executive Team with Appointments of U.S.-Based Chief Medical Officer and Chief Commercial Officer
Additions of Elyse Seltzer, M.D., as CMO and Robert Francomano as CCO Strengthen Company’s Presence in the U.S.Seasoned Team to Drive Forward ...
SynOx Therapeutics Adds New Investor and Capital to Series B Financing, Raising Total to $92 Million, and Doses First Patients in Phase 3 Trial
Gilde Healthcare Leads Series B Extension, Joining Premier Syndicate of Leading Life Science InvestorsFunding Supports Registrational Phase 3 ...
BBC1y
The GM chickens that lay eggs with anti-cancer drugs
The team has focused on two proteins that are essential to the immune system: one is IFNalpha2a, which has powerful antiviral and anti-cancer effects, and the other is macrophage-CSF, which is ...
Medscape23d
Tumor-associated Macrophages in Breast Cancer as Potential Biomarkers for New Treatments and Diagnostics
The presence of the CSF-1 receptor may identify both macrophages, as well as CSF-1-producing tumor cells. Identification of the CSF-1 receptor by immunohistochemistry in human breast tumors is ...
BBC11mon
Gene modified chickens 'lay medicines'
One is Macrophage-CSF. It is being is being developed as a therapy that stimulates damaged tissues to repair themselves. It is being produced in human and pig versions. The other is called ...
The American Journal of Managed Care17h
Fexagratinib in MS Shows Promise for Human Use
Previous research has highlighted the roles of the FGF, CSF, and VEGF signaling pathways in the pathology of MS. “In chronic ...
eLife3d
CD131 Contributes to Ulcerative Colitis Pathogenesis by Promoting Macrophage Infiltration
Ulcerative colitis (UC) is a chronic gut inflammatory condition affecting the colon in humans. This study uses human samples as well as a mouse model of colitis induced by a chemical, DSS, to ...
Business Wire19d
Savara Announces the Rare Lung Disease, Autoimmune Pulmonary Alveolar Proteinosis (aPAP), is Highlighted on a New Episode of “The Balancing Act ® ” Airing on Lifetime ® TV
Alveolar macrophages need to be stimulated by granulocyte-macrophage colony-stimulating factor (GM-CSF) to function properly in clearing surfactant, but in autoimmune PAP, GM-CSF is neutralized by ...
News Medical2d
Understanding metabolic alterations and immune dysfunction in acute-on-chronic liver failure
Acute-on-chronic liver failure (ACLF) is a life-threatening condition characterized by acute deterioration of liver function ...
Medscape1mon
Tumor-associated Macrophages in Breast Cancer as Potential Biomarkers for New Treatments and Diagnostics
These TAMs are polarized toward the M2 phenotype by CSF-1 and CCL2 ... 2011 Expert Reviews Ltd. Cite this: Tumor-associated Macrophages in Breast Cancer as Potential Biomarkers for New Treatments ...