A study has identified three new genes that regulate osteoclasts and are implicated in Paget disease; however, the clinical utility of these findings remains questionable. Paget disease of bone is ...

After withdrawal of treatment, relapse of Paget's disease, as judged by rising levels ... bisphosphonates do not prevent the recruitment of osteoclasts. The kinetics of relapse (as judged by ...

Specialized cells known as osteoclasts degrade the bone and ... which renews and strengthens the skeletal structure. In Paget’s disease, the balance between bone removal and bone building ...

The disease seems to occur in one of two patterns ... Numerous osteoblasts and osteoclasts are present and have been interpreted as exaggerated functional activity 2. The neurological signs ...