Specialized cells known as osteoclasts degrade the bone and ... which renews and strengthens the skeletal structure. In Paget’s disease, the balance between bone removal and bone building ...

A study has identified three new genes that regulate osteoclasts and are implicated in Paget disease; however, the clinical utility of these findings remains questionable. Paget disease of bone is ...

After withdrawal of treatment, relapse of Paget's disease, as judged by rising levels ... bisphosphonates do not prevent the recruitment of osteoclasts. The kinetics of relapse (as judged by ...

The cause of the disease appears to be a defect in bone reabsorption by the osteoclast, a specialized cell that normally helps maintain bone health. Paget’s disease is not a cancer. It is ...

Bone buildup keeps pace with bone breakdown. Paget’s disease destroys the equilibrium between breakdown and buildup. Osteoclasts go into a frenzy of demolition, gnawing at bones with abandon.

These conditions often result from the dysregulation of osteoclasts—specialized cells ... prevented bone loss in a RANKL-induced bone disease model. Notably, the peptide accumulated ...

Specialized cells known as osteoclasts degrade the bone and ... which renews and strengthens the skeletal structure. In Paget’s disease, the balance between bone removal and bone building ...

The cause of the disease appears to be a defect in bone reabsorption by the osteoclast, a specialized cell that normally helps maintain bone health. Paget’s disease is not a cancer. It is ...

Specialized cells known as osteoclasts degrade the bone and ... which renews and strengthens the skeletal structure. In Paget’s disease, the balance between bone removal and bone building ...

Your body constantly builds new bone to replace the old. But with Paget's disease, this happens too fast and gives your bones an odd shape. They may be bent, weak, brittle, soft, or too big.

It involves cells called osteoclasts, which break down the bone, and osteoblasts, which regrow new bone. Remodeling naturally slows down over time. But with Paget’s disease, the process is ...

Dear Doctors: I was recently diagnosed with Paget’s disease after suffering fatigue symptoms and muscle soreness in my neck, pelvic and lower-leg areas. I am sore and lethargic upon waking up in the ...