Paget's disease is frequently discovered because ... “hypermultinucleated” osteoclasts (arrowhead) adjacent to many osteoblasts (arrow), which synthesize matrix so rapidly that collagen ...

Specialized cells known as osteoclasts degrade the bone and ... which renews and strengthens the skeletal structure. In Paget’s disease, the balance between bone removal and bone building ...

A study has identified three new genes that regulate osteoclasts and are implicated in Paget disease; however, the clinical utility of these findings remains questionable. Paget disease of bone is ...

Figure 1: A photomicrograph of giant, detached, hypernucleated osteoclasts after long-term oral aminobisphosphonate therapy. Paget disease of bone, hyperparathyroidism, giant cell tumor and ...

which in turn leads to osteoclast changes that are seen in PD. The prevalence of Paget's disease has dropped during the past 25 years, Dr. Roodman said. That could reflect the impact of measles ...

which in turn leads to osteoclast changes that are seen in PD. The prevalence of Paget's disease has dropped during the past 25 years, Dr. Roodman said. That could reflect the impact of measles ...

Osteoprotegerin deficiency could explain juvenile Paget's disease because osteoprotegerin suppresses bone turnover by functioning as a decoy receptor for osteoclast differentiation factor (also ...

Paget’s disease was discovered 125 years ago by Sir James Paget. It occurs when osteoclasts at affected sites abnormally increase in size and number, which is thought to be caused by viral and ...

After withdrawal of treatment, relapse of Paget's disease, as judged by rising levels ... bisphosphonates do not prevent the recruitment of osteoclasts. The kinetics of relapse (as judged by ...

It involves cells called osteoclasts, which break down the bone, and osteoblasts, which regrow new bone. Remodeling naturally slows down over time. But with Paget’s disease, the process is ...

X denotes truncating mutation. PEST2 domain 345–377; UBA domain 387–436. *Two different mutations reported to cause this truncation. ‡ Results from splice site mutations (intron 7 ...

which in turn leads to osteoclast changes that are seen in PD. The prevalence of Paget's disease has dropped during the past 25 years, Dr. Roodman said. That could reflect the impact of measles ...