Sequential bone scans obtained between the ages of six and nine years were also unrevealing. ... Defective skeletal remodeling in patients with osteopetrosis compromises bone quality, ...

Malignant osteopetrosis, a severe disease causing early infantile death in humans, is caused by mutations in the TCIRG1, CLCN7, or OSTM1 genes. We have established the molecular basis of malignant ...

Malignant autosomal recessive (AR) osteopetrosis represents an absolute indication for bone marrow transplantation (BMT). Over the last 15 years, almost 100 BMTs for osteopetrosis have been reported.

St. Louis, July 31, 2003 -- A drug used to treat bone loss associated with diseases such as osteoporosis has caused a child to develop an unhealthy, dense skeleton characteristic of a condition ...

New Gene Defect Causes Heavy Bones Date: April 4, 2007 Source: Journal of Clinical Investigation Summary: Osteopetrosis is an inherited disorder whereby bones harden and become denser.

Cementless acetabular component fixation has been used because it does not require cancellous bone, which is sparse in osteopetrosis patients, for bone-cement fixation. [ 34 ] ...

Osteopetrosis is also called “marble bone disease.” In a Northern Russian Republic called Chuvash, one of every 4,000 newborns is reportedly born with this condition.

EXCESSIVE bone density - called osteopetrosis or marble bone disease - can cause vision loss, paralysis of facial muscles and even death. By Lauren Clark. 14:45, Tue, Sep 5, ...

Background Osteopetrosis is a rare, inherited, bone disorder, characterized by osteosclerosis, obliteration of the medullary cavity and calcified cartilage. The autosomal dominant form is ...