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Background Osteopetrosis is a rare, inherited, bone disorder, characterized by osteosclerosis, obliteration of the medullary cavity and calcified cartilage. The autosomal dominant form is ...
Under the microscope, medullary bone and bone with osteopetrosis look remarkably similar, Schweitzer said. However, the two are chemically different.
Autosomal-recessive intermediate osteopetrosis is a diffuse sclerotic disorder due to carbonic anhydrase deficiency and associated with renal tubular dysfunction and cerebral calcifications.
Figure 2: Tie2Cre-mediated PPAR-γ deletion leads to osteopetrosis represented by increased bone volume, decreased medullary cavity space and reduced bone resorption.
Osteopetrosis is a rare inherited bone disorder originally described in 1904 by Albers-Schonberg, ... It is recognized that the hard brittle bone, often without a normal medullary canal, ...
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