City of Hope researchers demonstrate proof of concept for a novel targeted therapy for pancreatic cancer, exploiting transcription-replication conflicts to combat treatment resistance.

Researchers have identified a new molecular target for treating pancreatic cancer. Scientists focused on transcription-replication conflicts (TRCs), which occur when the mechanisms responsible for ...

"This is a major advancement for pancreatic ductal adenocarcinoma," says senior ... Leiting et al, Molecular KRAS ctDNA Predicts Metastases and Survival in Pancreatic Cancer: A Prospective Cohort ...

Researchers at City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the U.S.

New research in JNCCN from The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center found ...

Scientists have identified a key vulnerability in pancreatic cancer by targeting transcription-replication conflicts—cellular ...

A new study focused on transcription-replication conflicts, which occur when mechanisms responsible for gene expression and genome duplication collide.

The use of ablative radiation therapy (A-RT) led to promising overall survival and effective local tumor control in patients ...

Pancreatic ductal adenocarcinoma (PDAC ... The patients experienced up to a 49% shrinkage in their liver metastases after taking the pill twice a day for two months. Overall, the experimental ...