Early work revealed that TFEB is highly effective in ameliorating tau/NFT pathology and rescuing cognitive impairment and neurodegeneration. TFEB targets only the aberrant tau species and this ...

The bar scale is 500 nm. (B) The proposed model illustrates how lysosomes and TFEB regulate MLRO in hepatocyte dedifferentiation. Increased amino acid levels from lysosomal degradation promote ...