which is normally folded and furrowed to fit more brain into a limited skull, instead has a smooth appearance (lissencephaly) and is often smaller than normal (microcephaly). The disease is ...

Lissencephaly is a spectrum of rare, genetic disorders in which the brain fails to develop its hallmark folds. The disorders are often associated with seizures and intellectual disability and ...

Lissencephaly means “smooth brain.” It is a brain abnormality wherein the brain’s outer layer has fewer folds. Conditions that can cause lissencephaly include Miller-Dieker syndrome and ...

This particular human specimen was smooth and resembled the brain of a smaller, less intelligent mammal. Looking closely at the genetics of this one patient, the scientists were able to identify ...