Infiltrative splenomegaly: Develops when substances that normally don’t enter the spleen, such as proteins and a form of glucose (sugar) called glycogen, enter the spleen and become trapped there.

Splenomegaly, or enlargement of the spleen, is common in patients with Philadelphia-negative myeloproliferative neoplasms, and it is associated with symptoms like early satiety and abdominal pain.

Hematological diseases can cause massive splenomegaly and portal hypertension via portal vein thrombosis, liver infiltration by malignant cells, or in association with NRH.

Splenomegaly and associated symptoms such as abdominal pain compromise the quality of life in patients with myelofibrosis, 17,19 and alleviation of these aspects of myelofibrosis by INCB018424 is ...

Since evaluation of splenomegaly still rests for the most part on physical examination however, it is believed that a technic often heretofore neglected in classic teaching should merit consideration.

New study findings indicate massive splenomegaly could have a profound impact on outcomes in patients with myelofibrosis (MF) who receive an allogenic hematopoietic cell transplantation (allo-HCT).

Splenomegaly, or an enlarged spleen, often occurs in connection with immune-related conditions and is seen in a variety of diseases, including autoimmune disorders and chronic infections.

A secondary cohort of 104 patients (62 men, 42 women; mean age, 56 years) with end-stage liver disease underwent pre-liver transplant CT from January 2011 to May 2013.

Splenomegaly retained its negative prognostic role in multivariate analysis of risk factors for thrombosis, as did previous thrombosis, leucocyte count, and male gender.

Automated splenic volume was 1,097 ml, above weight-based splenic volume threshold for determining splenomegaly of 350 ml. True-craniocaudal splenic length was 15.5 cm, and maximum-3D splenic ...

A broad spectrum of pathologies including hematologic malignancy, infection, and portal hypertension can lead to splenomegaly. 1-5 In patients with cancer, the onset of splenomegaly has important ...

Splenomegaly is an enlarged spleen. This can cause stomach discomfort, decreased blood flow and filtering, and anemia. It can even lead to a ruptured spleen, so taking precautions and seeing a ...