Early work revealed that TFEB is highly effective in ameliorating tau/NFT pathology and rescuing cognitive impairment and neurodegeneration. TFEB targets only the aberrant tau species and this ...

Details are provided in a new Cell paper titled, “CD36-mediated endocytosis of proteolysis-targeting chimeras.” PROTACs are small molecules that use the ubiquitin-proteasome system to remove ...

Activated p53 negatively regulates mTORC1 signaling, which is one of the major kinases responsible for the phosphorylation of TFEB and TFE3. The autophagy-lysosomal pathway is activated via the ...