Double-edged STING: A new pathway involved in aging
"In response to STING activation, cells used TFEB and TFE3 to produce more lysosomes and increase autophagy." Both lysosomes ...
Baylor College of Medicine2mon
TFEB and V-ATPase-mediated Lysosomal Stress Sensing Pathway in Tauopathy
This project is to determine TFEB PTM signatures induced by tau that drive TFEB nuclear signaling. The hypothesis is that intraneuronal Tau accumulation acts as a lysosomal stress signal to activate ...
Baylor College of Medicine3y
Lysosomal Metabolomics and pH Core: Program Project Grant
The core will study TFEB-mediated lysosome-to-nucleus signaling in aging and lifespan regulation based on FLIM-based imaging platform. The goal is to determine the association between lysosomal pH and ...