in three patients with EGFR-expressing glioblastoma. The 72-year-old male patient had undergone standard therapies, only to have his tumor return. MRI scans taken just a day after receiving the ...
her team engineered these CAR-T cells to deliver TEAMs against wild-type EGFR, which is not detected in normal brain tissue but is expressed in more than 80% of cases of GBM. The combination ...
Recent advances in the understanding of molecular and cytogenetic pathways that influence tumor growth, invasion, angiogenesis and apoptosis have led to the direct targeting of the aberrant ...
That was on Nov. 25. This time, Chen, as part of a clinical trial at Rhode Island Hospital used a radiation treatment, on the ...
and the programme joins an increasing body of drugs that have failed to move the needle in glioblastoma. That includes several small-molecule and antibody-based EGFR inhibitors, including ImClone ...