In this study, we demonstrated simvastatin-induced G0/G1 arrest by inducing p21 and p27 accumulation in HepG2 and Hep3B cells. Simvastatin also promoted AMP-activated protein kinase (AMPK ...

"A Postsynaptic AMPK?p21-Activated Kinase Pathway Drives Fasting-Induced Synaptic Plasticity in AgRP Neurons." Neuron. 2016 Jun 16 [Epub ahead of print] pii: S0896-6273(16)30204-5. doi: 10.1016/j ...

The function of p21 is to stop or slow down the cell cycle until energy levels are restored to normal. The same mechanism occurs at other genes regulated by AMPK, allowing direct control of the ...

Cancer often results in weight loss due to unwanted metabolic complications. This so-called cancer cachexia is accompanied by a poor prognosis with regard to disease progression, quality of life ...

The findings suggest that the drug has context-dependent effects on cancer cells. The results, entitled "AMPK activation by metformin promotes survival of dormant ER+ breast cancer cells," are ...

This study concludes that activation of the PPARβ/δ-AMPK pathway is an effective strategy to slow the development of liver fibrosis. The paper, published in the journal Biomedicine ...

“AMPK is a high-value target for the treatment of metabolic diseases, and drug developers have faced challenges for many years in identifying isoform-selective AMPK activators for tissue ...