AMPK, an important kinase that regulates energy homeostasis ... (D and B), as further confirmed by lower levels of p53 and its downstream genes (p16, p21 and p27) (Yadav et al., 2020). Taken together, ...

The intrinsic factor of cell senescence, PCBP2, was identified by unlabeled quantitative proteomics, and its biological role in in vitro replication senescence of human bone marrow mesenchymal stromal ...

Here, we found that inhibition of AMPK occurs during naïve transition with two conventional inhibitors of the MEK1 and GSK3β pathways. The accumulation of glycogen due to iGSK3β is responsible for ...

Icaritin (ICA) is a prenylflavonoid natural product extracted from plants of the Epimedium genus. The approval of ICA softgel capsules as a class 1.2 traditional Chinese medicine (TCM) innovative drug ...

UPMC Hillman Cancer Center, University of Pittsburgh, 5115 Centre Ave, Pittsburgh, Pennsylvania 15232, United States Department of Computational and Systems Biology, University of Pittsburgh, 3420 ...

Loss of adiponectin effect in obesity also increases renal oxidative stress, fibrosis, and inflammation. Adiponectin-mediated AMPK activation is responsible for many of adiponectin's renoprotective ...