But they found that, unlike chromosomes, ecDNA transcription — the process of copying DNA sequences into RNA instructions ...

POLK expression in neurons and report an important observation that POLK exhibits an age-dependent change in subcellular localization, from the nucleus in young tissue to the cytoplasm in old tissue.

Finally, the researchers describe a way to exploit ecDNA’s high rate of replication and transcription: a conflict between DNA ...

Can small circles of DNA, once dismissed as irrelevant, actually be major contributors to cancer development? Three new research studies ... | Genetics And Genomics ...

Katelyn Chew looks at how new research is helping us understand the ability of DNA to reshuffle in the nucleus using CRISPR ...

Cells synthesise messenger RNA (mRNA) using instructions in DNA and then ‘read’ instructions from the mRNA to make functional ...

Stanford Medicine researchers discovered that extrachromosomal DNA (ecDNA) significantly drives cancer growth. By analyzing nearly 15,000 human cancers, they found that ecDNAs impact tumor behavior ...

Transcription activation of genes by estrogens is driven by enhancers, which are often located within the same Topologically Associating Domain (TAD) as non-targeted promoters. We investigated how ...

Tiny circles called ecDNA are critical in cancer development and drug resistance. An international team publishes landmark studies detailing new findings and potential therapies.

Some bacteria can cause mutations associated with colon cancer. Insights about the surface adhesion proteins that enable ...