The major ocular finding of Marfan syndrome (MFS) is ectopia lentis, and approximately 60% of patients have lens dislocation, which is usually superior and temporal; this may be present at birth ...

Ectopia lentis (EL) is a condition that can either herald underlying systemic conditions, or be isolated. The recent expansion in the genetics of these conditions has furthered the understanding ...

"Biallelic mutations in the LTBP2 gene have been associated with microspherophakia and early ectopia lentis in patients with a Marfan-like phenotype (tall stature, high-arched palate, long arm ...

Ectopia lentis (lens dislocation) and aortic root dilation or dissection are cardinal features of MFS. Distinguishing MFS from other HCDTs has important implications for treatment, as ...

When these fibers loosen, it leads to the partial dislocation of the lens (called ectopia lentis), resulting in iridodonesis. The weakened ciliary zonules in Marfan’s syndrome thus lead to lens ...