Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly ...

MVB trafficking is controlled by Rabs and SNARE‐complexes for secretion of exosomes at the cell surface ... These EVPs collectively form a reservoir of biomarkers to be mined for early cancer ...

Scientists have discovered exactly how earthquakes trigger quartz into forming large gold nuggets — finally solving a mystery that's puzzled researchers for decades.

Moreover, the encouragement towards opening for the transfer of both matter, i.e. substance, and information, i.e. form, requires significantly intensified transdisciplinary cooperation between ...

They then interrogate the role of the phosphorylation of S1086 in the arginine-rich DAD of FMNL1betaby introducing S1086A and S1086D mutations that, respectively, cannot be phosphorylated or mimic the ...

were differentiated into motor neurons on top of the muscle sheet to form NMJs. We evaluated the impact of neural innervation on muscle contraction and metabolism, myokine-encoding messenger RNA (mRNA ...

High centrifugal force can damage exosome integrity Charge neutralization-based precipitation (commercial kits) 32,33 Based on the principle of compound polymerization precipitation. Samples are mixed ...

However, whether KIBRA may influence Aβ metabolism by regulating exosome secretion has not been systematically explored ... in MVBs are transported to lysosomes and degraded to non-toxic form.

Exosomes originate as intraluminal vesicles (ILVs) that form by inward budding of the limiting membrane ... In obesity, these organs or tissues increase the secretion of exosomes that promote insulin ...