As these clinical trials mature and continue to enroll patients, we expect to leverage our internal clinical operations capabilities across these trials and functions ... what would be expected from ...

selinexor primarily functions by blocking the export of TP53 from the nucleus to the cytoplasm. When TP53 accumulates in the nucleus, it leads to disrupted DNA repair processes, cell cycle arrest ...

Circle Pharma, a clinical-stage biopharmaceutical company dedicated to discovering and developing a new generation of macrocycle therapies, today announced that preclinical data from its lead ...

The faithful replication and segregation of the DNA is dependent on the existence of checkpoints that monitor the accuracy of these events and prevent cell-cycle progression when problems arise.

The pre-clinical data shows CID-078 demonstrated single-agent tumor activity across tumor cell line and in vivo models with dysregulated cell cycle (CDK-RB-E2F) function. Notably, tumor ...

Tsingke has delivered high-quality biotechnology services and products to nearly 300,000 users globally. The number of high-level academic papers published ...

The N-AVD regimen showed improved progression-free survival and lower toxicity than BV-AVD in advanced Hodgkin lymphoma, ...

Immune checkpoint inhibitors ... by acute deterioration of liver function in patients with pre-existing chronic liver disease. Head and neck squamous cell carcinoma (HNSCC) ranks as one of the ...

Inhibition of CDK6 may prevent arteriovenous malformations in hereditary hemorrhagic telangiectasia by regulating endothelial ...