In people with SCD, certain mutations within the HBB gene can change the structure of the hemoglobin. Specifically, mutations code for an abnormal version of beta-globin, or HbS. This might occur ...

The HBB gene is located in the short arm of chromosome ... Because Hb is abundant in red blood cells, the abnormal structure of Hb affects the red blood cell structure, function and survival.

The Chinese researchers, from Sun Yat-sen University in Guangzhou, were attempting to modify a mutant form of a gene called HBB. Certain mutations prevent people from producing enough hemoglobin ...

It is inherited in an autosomal recessive pattern involving the HBB (hemoglobin subunit beta) gene. Your chances of carrying or inheriting the beta thalassemia minor trait depend on whether one or ...

In a form of sickle cell disease called sickle cell anemia, mutations in a gene called HBB affect the protein’s structure, causing it to twist normally round red blood cells into a curved sickle ...

But a mutation in a single gene, the HBB gene, makes hemoglobin stack in long strings inside blood cells, giving them an inflexible, sickle shape. Instead of being “squishy,” the stiff red ...

SCD is caused by a single point mutation in the HBB gene, which encodes the β subunit of hemoglobin (Hb). Normally, red blood cells adopt a disc-like shape that allows them to move easily through ...

So the Chinese scientists tried using CRISPR/Cas9 to fix a gene known as the HBB gene, which causes beta thallasemia. The work was done on 86 very early embryos that weren't viable, in order to ...