During the first step of converting genetic information into functional proteins, cells transcribe the double-stranded helix ...

A large molecular machine, the spliceosome, distinguishes introns from exons, removes the former and joins the latter to create a mature mRNA template. Cells can fine-tune these complex splicing ...

Two molecular control factors play a decisive role in what is known as splicing, the cutting and assembly of mature messenger ...

The introns need to be cut out of the pre-mRNA in the cell nucleus and the exons reconnected at the interfaces. This process is known as splicing.

While working on a COVID-19-related project during the lockdown, Kärt Tomberg, PhD, found herself thinking about introns. She was part of a team working on the spike protein used in vaccines.

“Almost all human genes produce RNA transcripts that undergo the process of splicing, whereby coding segments, called exons, are joined together and non-coding segments, called introns, are removed ...

Pseudo splice sites and cryptic splicing “The human genome has introns that are significantly longer than exons. These long introns contain numerous small segments, called pseudo splice sites, that ...

The exons contain the important instructions for making proteins, and to make RNA, cellular machinery typically "splices" out the introns, leaving only exons behind.

Shown is the splicing pathway. The pre-messenger RNA (pre-mRNA) has exons (blue) and introns (pink). The spliceosome (not shown) was known to catalyze two chemical reactions (black arrows) in a ...

The human genome has hundreds of thousands of introns, about 7 or 8 per gene, and each is removed by a specialized RNA protein complex called the “spliceosome” that cuts out all the introns and ...

In the genome, genes that code for protein are often divided into sections called exons, which are separated by spacers called introns. When a region of DNA is transcribed into messenger RNA (mRNA) or ...

The human genome comprises ~20,000 genes. Genes consist of exons, DNA bases that encode protein, which are separated by introns – non-coding DNA sequences. When a gene is transcribed, a process called ...