Background: Studies indicate that Merkel cell polyomavirus (MCPyV) infection is a causative factor for the development of virus-positive Merkel cell carcinoma (VP MCC). This neuroendocrine neoplasm ...

Among patients with MCC, approximately 80% have Merkel cell polyomavirus. “Most of us have come in contact with it at some point,” Padi said.

Merkel cell carcinoma is a rare but fast-growing neuroendocrine cancer that is three to five times more likely than melanoma to be deadly. Response rates to current therapies—surgery, radiation ...

Merkel cell carcinoma is increasing in incidence. Even though it's a rare cancer type, it mimics a lot of properties that other cancers have." ...

McEvoy AM, Lachance K, Hippe DS, et al. Recurrence and Mortality Risk of Merkel Cell Carcinoma by Cancer Stage and Time From Diagnosis. JAMA Dermatol. 2022;158 (4):382-389.

Moving MCC research forward Launched on January 27, the Merkel Cell Carcinoma Collaborative (MC3) Institute represents the next chapter in MCC research and care at UW Medicine and Fred Hutch. By ...

Ambient ultraviolet radiation exposure and Merkel cell polyomavirus were both attributed to the development of Merkel cell carcinoma, whereas HIV, organ transplants and lymphocytic leukemia were ...

Merkel cell carcinoma is caused by expression of two viral genes: small and large tumor antigens, often referred to as small T and large T. However, it wasn’t until about 5 years after Merkel cell ...

Key Takeaways ctDNA testing effectively stratifies Merkel cell carcinoma patients into high and low recurrence risk categories, influencing surveillance strategies. The study's cohorts revealed ...

Merkel cell carcinoma is a rare but highly aggressive form of skin cancer known for its rapid growth and tendency to metastasize. Despite the promise of immune checkpoint blockade therapy, which ...

Journal reference: Reinstein, Z. Z., et al. (2024) Pre-existing skin-resident CD8 and γδ T cell circuits mediate immune response in Merkel cell carcinoma and predict immunotherapy efficacy.