Subsequently, the analysis of single-gene defects arising by spontaneous mutations in inbred strains moved to the forefront of mouse genetics research (see Refs 3,4 for excellent historical ...

1.2.2 Castle, Little, and the founders of mouse genetics The most significant force in early genetic work on the mouse was William Ernest Castle, who directed the Bussey Institute at Harvard ...

Making Mice is, to a large extent, the story of Clarence Cook Little and his effort to establish standardized inbred mouse lines as essential resources in the study of genetics and cancer.

The significance of the interspecific cross for mouse genetics cannot be understated: it was the single most important factor in the development of a whole genome linkage map based on molecular ...

Mouse Genetics Core Facility (MGCF) at Memorial Sloan-Kettering Cancer Center (MSKCC) provides a range of technical support to facilitate the use of genetically engineered mice (GEM) for in vivo ...

Scientists looking to bring the extinct woolly mammoth back to life have made adorable progress—using gene editing to create a "woolly mouse." The team at genetics and biotech firm Colossal ...

Genetics hold far more sway over the mouse microbiome than transient environmental exposures, researchers reported July 26 in Applied and Environmental Microbiology. The results appear to contradict ...