Subsequently, the analysis of single-gene defects arising by spontaneous mutations in inbred strains moved to the forefront of mouse genetics research (see Refs 3,4 for excellent historical ...

1.2.2 Castle, Little, and the founders of mouse genetics The most significant force in early genetic work on the mouse was William Ernest Castle, who directed the Bussey Institute at Harvard ...

Current research in mouse behavioural genetics is directed towards understanding the molecular mechanisms that govern complex behaviours, such as biological rhythms, anxiety, and learning and ...

“While we know a lot about mouse genetics, we know much less about mammoths and elephants. It isn’t yet known which sections of the genome are vital for achieving the characters ...

De-extinction startup Colossal Biosciences has gene-edited mice to have mammoth-like features, creating what the company calls the Colossal Woolly Mouse. The lab mice, which have been modified to ...

Scientists looking to bring the extinct woolly mammoth back to life have made adorable progress—using gene editing to create a "woolly mouse." The team at genetics and biotech firm Colossal ...

Finally, the in vivo relevance of these regulators and their potential as reactive astrocyte targeted therapeutics is determined using mouse genetics and mouse models of disease. Ultimately, my lab ...