Paget's disease is frequently discovered because ... “hypermultinucleated” osteoclasts (arrowhead) adjacent to many osteoblasts (arrow), which synthesize matrix so rapidly that collagen ...

A study has identified three new genes that regulate osteoclasts and are implicated in Paget disease; however, the clinical utility of these findings remains questionable. Paget disease of bone is ...

which in turn leads to osteoclast changes that are seen in PD. The prevalence of Paget's disease has dropped during the past 25 years, Dr. Roodman said. That could reflect the impact of measles ...

Specialized cells known as osteoclasts degrade the bone and ... which renews and strengthens the skeletal structure. In Paget’s disease, the balance between bone removal and bone building ...

which in turn leads to osteoclast changes that are seen in PD. The prevalence of Paget's disease has dropped during the past 25 years, Dr. Roodman said. That could reflect the impact of measles ...

Osteoprotegerin deficiency could explain juvenile Paget's disease because osteoprotegerin suppresses bone turnover by functioning as a decoy receptor for osteoclast differentiation factor (also ...

It involves cells called osteoclasts, which break down the bone, and osteoblasts, which regrow new bone. Remodeling naturally slows down over time. But with Paget’s disease, the process is ...

After withdrawal of treatment, relapse of Paget's disease, as judged by rising levels ... bisphosphonates do not prevent the recruitment of osteoclasts. The kinetics of relapse (as judged by ...

which in turn leads to osteoclast changes that are seen in PD. The prevalence of Paget's disease has dropped during the past 25 years, Dr. Roodman said. That could reflect the impact of measles ...

Specialized cells known as osteoclasts degrade the bone and ... which renews and strengthens the skeletal structure. In Paget’s disease, the balance between bone removal and bone building ...

In Paget's disease the osteoclasts become more active than the osteoblasts creating a discrepancy between bone breakdown and formation. This means that there is more bone breakdown than usual.

Paget's disease of bone was first described by Sir James Paget in ... in which bony tissue is broken down or resorped by osteoclasts, followed by the formation of new well-structured bony tissue by ...