X denotes truncating mutation. PEST2 domain 345–377; UBA domain 387–436. *Two different mutations reported to cause this truncation. ‡ Results from splice site mutations (intron 7 ...

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Paget’s generally "burns out" in time, causing no additional pain or damage. Any damage the disease has already caused, however, is irreversible. About one million people in the United States have ...

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Environmental factors such as lifestyle and the medications you take influence the effects your genes have on your body − and can clarify how diseases develop.

The goal is to reuse key parts of the treatment and simply swap in a custom set of instructions for each patient's specific gene mutation, doctors say.