Genome-wide effects of trisomy 21; RNA-based signs of transgenerational stress; depression and resilience; a call to overhaul US biomedical research system A series of rodent experiments showed that ...

A century after Down syndrome was first described, scientists discovered that the root cause of this disorder is a condition called trisomy 21. What strides in research have been made since then?

Background: Trisomy 18 is the second most common autosomal trisomy in liveborn infants, characterised by severe psychomotor and growth retardation. The median survival is 19 days, with only 5-8% ...