and the expression levels of CD36 and SR-A were decreased to inhibit lipid uptake, both of which were prevented by TFEB knockdown. These results indicated that TFEB nuclear translocation activated ...

How these EC immune cells can contribute to the brain immunity when implicated by CD36 (an innate immune receptor) is widely unknown. To understand this question, we wanted to investigate how CD36 ...

A study identifies metastasis-initiating cells through a specific marker, namely the protein CD36. This protein, which is found in the membranes of tumor cells, is responsible for taking up fatty ...

Early work revealed that TFEB is highly effective in ameliorating tau/NFT pathology and rescuing cognitive impairment and neurodegeneration. TFEB targets only the aberrant tau species and this ...

In this novel process, drug molecules are designed to better engage with CD36, a protein receptor found on the surface of many cells. By optimizing chemical interactions with CD36, the team was ...

Details are provided in a new Cell paper titled, “CD36-mediated endocytosis of proteolysis-targeting chimeras.” PROTACs are small molecules that use the ubiquitin-proteasome system to remove ...

Overview: Both mitochondrial and lysosomal stress stimulate TFEB nuclear translocation, followed by increased HKDC1 expression. HKDC1 stabilizes PINK1 through interaction with TOM70, thereby ...

HKDC1, a target of TFEB, is essential to maintain both mitochondrial and lysosomal homeostasis, preventing cellular senescence. Proceedings of the National Academy of Sciences , 2024; 121 (2) DOI ...