eLife16d
Small-molecule Activation of TFEB Alleviates Niemann-Pick Disease Type C via Promoting Lysosomal Exocytosis and Biogenesis
This study reports that activation of TFEB promotes lysosomal exocytosis and clearance of cholesterol from lysosomes, the strength of evidence for which is convincing with appropriate and validated ...
Frontiers5d
Targeting amino acid metabolism to inhibit gastric cancer progression and promote anti-tumor immunity: a review
1 Department of Oncology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China 2 Institute of Digestive Diseases, Jiangsu University, Zhenjiang, China The incidence of gastric cancer ...
Frontiers11d
Ferroptosis, pathogenesis and therapy in AS co-depression disease
Ferroportin-1, a ferroptosis inhibitor, countered these effects. PGPC triggers ferroptosis through the CD36 receptor, impairing endothelial function (Chen et al., 2024). Iron accumulation from ...
Medscape16d
Prostaglandins, leukotrienes, and essential fatty acids
ISSFAL Official Statement Number 6: The importance of measuring blood omega-3 long chain polyunsaturated fatty acid levels in research.
LinkedIn15d
Isadora Cavalcante’s Post
IKKα is a master regulator of diverse biological processes, but the significance of its activity in human physiology has remained a mystery...until now 🔮⬇️ A study published in Nature ...
LinkedIn17d
Jeya Chelliah’s Post
A Novel “Genomic Tag and Trap” Strategy to Overcome Neoantigen Evasion January 23, 2025 Jeya Chelliah B.VSc Ph.D. Neoantigens are tumor-specific peptide fragments arising from somatic ...