Baylor College of Medicine2mon
TFEB and V-ATPase-mediated Lysosomal Stress Sensing Pathway in Tauopathy
This project is to determine TFEB PTM signatures induced by tau that drive TFEB nuclear signaling. The hypothesis is that intraneuronal Tau accumulation acts as a lysosomal stress signal to activate ...
Baylor College of Medicine3y
Lysosomal Metabolomics and pH Core: Program Project Grant
The core will study TFEB-mediated lysosome-to-nucleus signaling in aging and lifespan regulation based on FLIM-based imaging platform. The goal is to determine the association between lysosomal pH and ...
EurekAlert!10mon
A scheme for the autophagy machinery in mammalian cells. (IMAGE)
Autolysosomes then undergo ALR and lysosome biogenesis mediated by TFEB. ALR, autophagic lysosome reformation; ER, endoplasmic reticulum; ESCRT, endosomal sorting complexes required for transport ...