Axons of dopaminergic neurons projecting from substantia nigra to striatum are severely affected in the early stage of Parkinson's disease (PD), with axonal degeneration preceding the loss of cell ...

The biotech is focusing on precision, small-molecule medicines that work via a process known as cellular clearance by activating the lysosome, sometimes referred to as the cell’s recycling and ...

circLOC375190 affects AIS autophagy by regulating the mTORC1/TFEB axis. Therefore, to provide a theoretical foundation for the treatment of AIS, the authors explored the specific mechanism of ...

For instance, key signaling pathways such as MAPK, JAK/STAT, Notch, and NF-κB, etc. And some key regulatory proteins such as MERTK, TFEB, etc. Current experiments have shown that p53 and JNK need to ...

In summary, exercise regulates autophagy-lysosome function by activating pathways such as AMPK, PI3K/Akt, and TFEB, thereby promoting the clearance of pathogenic proteins, reducing neuronal damage, ...

Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration.

National Engineering Research Center of Ophthalmology and Optometry, School of Biomedical Engineering, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China ...

School of Chemistry and Chemical Engineering, Hunan Key Laboratory for the Design and Application of Actinide Complexes, University of South China, 28 Changsheng West Road, Hengyang, Hunan 421001, P.