Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly ...

and BeiGene’s Brukinsa (zanubrutinib), two BTK inhibitors used as second-line therapies after initial therapy chemotherapy or proteasome inhibitors such as Takeda’s Velcade (bortezomib).

Like March-I, CD83 is a known regulator of MHC-II expression in APCs and we also show that CD83 suppresses endogenous March-I-dependent MHC-II ubiquitination, endocytosis, and degradation in mouse ...

For more expert insights, check out this ultimate guide to the Florida expungement process. The initial step in the process is to apply to the Florida Department of Law Enforcement (FDLE) for a ...

We will explore how the choice of linker and the recruitment of specific E3 ligases significantly influence selectivity, as well as how the ubiquitination process ... selectivity and induces PTPN2 ...

The majority of heatwaves took place between 2006 and 2015, causing widespread coral bleaching and reef degradation. In 2021, nearly 60 percent of the world’s ocean surface experienced at least ...

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