Manny Machado and the San Diego Padres square off against the Chicago White Sox and starter Chris Flexen on Saturday at 8:40 ...

The San Diego Padres (88-66) take on the Chicago White Sox (36-118), who will be trying to halt a three-game losing streak, ...

The Chicago White Sox staged a two-out rally in the 9th but fell to the San Diego Padres 3-2 in 10 on Friday. The Sox are ...

Manny Machado’s San Diego Padres play the Chicago White Sox on Sept. 21 at 8:40 PM ET, and will see starting pitcher Chris ...

Lenyn Sosa hit a tying two-run homer with two outs in the ninth inning, but the Chicago White Sox lost their 118th game when ...

Fernando Tatis Jr.'s run-scoring hit leading off the 10th lifted the Padres to a 3-2 victory over the White Sox Friday.

Preview the Sept. 21 matchup between the San Diego Padres and Chicago White Sox with odds over/under, game spread, betting ...

The Chicago White Sox are closing in on matching the 1962 New York Mets for the most losses in modern-day Major League ...

What unfolded Friday night at Petco Park was not a particularly well-played baseball game, which you would half-expect ...

Chicago White Sox (36-118, fifth in the AL Central) vs. San Diego Padres (88-66, second in the NL West) San Diego; Saturday, 8:40 p.m. EDT PITCHING PROBABLES: White Sox: Chris Flexen (2-14, 5.09 ERA, ...

The Chicago White Sox trailed by two runs as Sosa batted with a runner on and two outs in the ninth inning against the San Diego Padres at Petco Park. After a ball, Sosa fouled off the next three ...

Analyzing Friday’s Chicago White Sox at San Diego Padres odds and lines, with MLB expert picks, predictions and best bets.