In Week 10, running back Isaac Guerendo and the San Francisco 49ers' rushing attack will square off against the Tampa Bay ...

In Week 11, running back Isaac Guerendo and the San Francisco 49ers' rushing attack will square off against the Seattle ...

When the Seahawks take the field against the 49ers on Sunday, they'll do so with three new starters on the defense that got ...

Guerendo had one carry for zero yards in Sunday's 23-20 win over Tampa Bay. With star running back Christian McCaffrey (Achilles) returning to action and backup Jordan Mason (shoulder) healthy, ...

San Francisco 49ers running back Isaac Guerendo joined the 49ers "You've Got Mail" podcast presented by Delta Dental to discuss his journey to the pros, the early contributions of the rookie class and ...

ANALYSIS: San Francisco 49ers running back Isaac Guerendo has barely seen the field as a rookie. He is the RB63 for the year, ...

San Francisco 49ers running back Christian McCaffrey is set to make his season debut on Sunday against the Tampa Bay ...

John Lynch revealed what Christian McCaffrey's impending return might mean for backup San Francisco 49ers running backs Jordan Mason and Isaac Guerendo.

The snap share he took on in Week 10 (88 percent) indicates he's able to handle a full workload, as he ceded just two carries (for five yards) to reserve backs Jordan Mason and Isaac Guerendo.

T Trent Williams, OL Dominick Puni, RB Isaac Guerendo and K Jake Moody discussed the mentorship within the team, the renewed energy from RB Christian McCaffrey's return and the team's mindset heading ...

Running back Patrick Taylor Jr. re-signed with the 49ers on their practice squad. To make room on the 16-man practice roster, ...