Hundreds of workers at the National Institutes of Health on Monday openly protested the Trump administration’s cuts to the agency and consequences for human lives, writing in a sharply worded letter that its actions are causing “a dramatic reduction in life-saving research.

On Monday, scores of scientists at the agency sent their Trump-appointed leader a letter titled the Bethesda Declaration, challenging “policies that undermine the NIH mission, waste public resources, and harm the health of Americans and people across the globe.”