Background Acute-on-chronic liver failure (ACLF) is a life-threatening syndrome involving dysfunction of multiple immune cell ...

Portal venous pressure (PVP) measurement is essential for the management of cirrhosis-related portal hypertension. Unlike indirect assessments using hepatic venous pressure gradient (HVPG) ...

Background Cholecystectomy is commonly performed globally, and many patients with disorders of gut-brain interaction (DGBI) report that their symptoms have either preceded or developed following ...

Introduction Artificial Intelligence (AI) has significantly revolutionized healthcare, particularly in diagnosing and treating Irritable Bowel Syndrome (IBS) and various digestive ailments. Vital AI ...

Objective To compare efficacy of pharmacotherapies for chronic idiopathic constipation (CIC) based on comparisons to placebo using Bayesian network meta-analysis. Data sources We conducted searches ...

Objective We developed a validated index for assessing histological disease activity in UC and established its responsiveness. Methods Two hundred biopsies were scored. The outcome was the Global ...

Background: The colonic epithelium maintains a life long reciprocally beneficial interaction with the colonic microbiota. Disruption is associated with mucosal injury. Aims: We hypothesised that ...

Objectives To investigate the occurrence of postinfectious IBS in routine outpatient care, comparing different types of GI infection and its interaction with psychosomatic comorbidity. Design ...

Background: Recent data have outlined a relationship between the composition of the intestinal microflora and allergic inflammation, and demonstrated the competence of probiotics in downregulation of ...

Conventional white-light endoscopy has high interobserver variability for the diagnosis of gastric precancerous conditions. Here we present a deep-learning (DL) approach for the diagnosis of atrophic ...

Objective Serrated lesions such as sessile serrated adenomas or polyps (SSA/Ps) are important colorectal cancer precursors, but aetiological factors for these lesions are largely unknown. We aimed to ...

BACKGROUND Endoscopic oesophageal changes are diagnostically helpful and identify patients exposed to the risk of disease chronicity. However, there is a serious lack of agreement about how to ...