In this study, we demonstrated simvastatin-induced G0/G1 arrest by inducing p21 and p27 accumulation in HepG2 and Hep3B cells. Simvastatin also promoted AMP-activated protein kinase (AMPK ...

"A Postsynaptic AMPK?p21-Activated Kinase Pathway Drives Fasting-Induced Synaptic Plasticity in AgRP Neurons." Neuron. 2016 Jun 16 [Epub ahead of print] pii: S0896-6273(16)30204-5. doi: 10.1016/j ...

The function of p21 is to stop or slow down the cell cycle until energy levels are restored to normal. The same mechanism occurs at other genes regulated by AMPK, allowing direct control of the ...