The Thermo Scientific picoSpin 45 NMR spectrometer is a useful tool for teaching through the aldol condensation reaction. In a number of undergraduate organic teaching programs, probably the first ...

One long-standing unsolved challenge is the enantioselective aldol reaction of fluoroacetate to enable access to fluorinated analogues of medicinally relevant acetate-derived compounds ...

Organic synthesis is based on carbon-carbon bond formation. Aldol condensation is one of the key reactions, forming a new β-hydroxy carbonyl compound through the reaction of two carbonyl compounds.

Finally, oxidative workup of the resultant boron aldolate provides aldol adduct. The reaction procedure requires approximately 28 h to complete over a 2-d period, consisting of 5 h to set up the ...