This variant, which usually affects people of a younger age, is frequently associated with mutations located within the P2 region of the alpha-synuclein, such as the G51D mutation, which produces ...

Previously, this mutation had been spotted only in a few ... such as toxic clumps of alpha-synuclein protein. In typical Parkinson's, alpha-synuclein builds up in the brain, forming sticky clumps ...

Parkin is an E3-type ubiquitin protein ligase that is involved in the degradation of specific proteins, including alpha-synuclein, a primary component of Lewy bodies. Mutations in PRKN are thought ...

Study reveals alpha-synuclein's role in enhancing DNA repair in melanoma, linking Parkinson's protein to cancer cell survival ...

The test – which detects a misfolded form of alpha-synuclein – could eventually ... was that 30% of participants with the LRRK2 gene mutation – which causes a disease with Parkinson-like ...

Nitrated α-synuclein is upregulated in the CSF of patients with Parkinson’s Disease (PD), Lewy body dementia (DLB), multiple system atrophy (MSA), and other synucleinopathies.