Targeting these pathways holds the promise to improve cellular therapies for TP53-mutant myeloid neoplasms. TP53 deficiency in AML cells leads to CAR T-cell exhaustion and ultimately AML resistance ...

This review describes therapeutically relevant mechanisms of action of botulinum toxin (BT). BT's molecular mode of action includes extracellular binding to glycoproteine structures on cholinergic ...

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The final look has introduced the concept of mutant dinosaurs to the franchise. Dinosaurs that were considered too dangerous for the Jurassic Park and Jurassic World theme parks now roam free on ...

Tactical Takedown reinvents the franchise with a strong new direction, combining turn-based strategy and beat-em-up combat. With both Splinter and Shredder dead and the Turtles nearing adulthood, ...

This is a new mutant dino created for Jurassic World Rebirth that’s a bit like a cross between a T-Rex and a Rancor from Star Wars. “It’s kind of like if the T-Rex was designed by H.R. Giger ...

HD is an autosomal dominant disorder caused by a mutation in the gene encoding HTT resulting in expansion of the polyglutamine (polyQ) stretch on its amino-terminus (Bates et al., 2015; Franklin et al ...

AUSTIN (KXAN) — In a 107-39 vote, the Texas House approved a measure to enhance patient safety and tighten Texas law over who can administer Botox injections — and similar treatments.