Strain amplifies tetravalent carbon atoms’ ability to donate electrons, facilitating various non-covalent interactions, quantum chemical calculations show. ‘Usually when a carbon atom is in a ...

The site-selectivity classification task is optimized alongside with two molecular property regression tasks of reaction substrates (arene and electrophile). These two regression tasks which is ...

Researchers from Auburn University have found a new pathway to use visible blue light to promote nickel catalyzed cross-coupling of activated heteroarenes with aryl iodides. This would be highly ...

Electrochemical transformations use electricity rather than chemical reagents to perform reactions. Both of the new reactions are cross-electrophile couplings, which wed two different electrophiles.

First published in 2016, the T-REX method releases a specific electrophile to a target protein, the ramifications of which can be observed in space and time, and in live cells.

Alkyl chlorides and aryl chlorides are among the most abundant and stable carbon electrophiles. Although their coupling with carbon nucleophiles is well developed, the cross-electrophile coupling of ...

Cross-electrophile coupling reactions of two Csp3–X bonds remain challenging. Herein we report an intramolecular nickel-catalyzed cross-electrophile coupling reaction of 1,3-diol derivatives. Notably, ...